The Science

133+ markers.
12 biological domains.
Read as a system.

Meden does not read your variants in isolation. Every genetic marker is interpreted in the context of every other — because your biology does not work in isolation either. This is the science behind your longevity protocol.

How a genetics specialist
reads your genome.

Consumer genetic testing gives you data. Meden gives you interpretation. There is a significant difference between knowing you carry a COMT Val158Met variant and understanding what that means alongside your MAOA, your BDNF, your NR3C1, and your current bloodwork.

Every Meden report begins with a full read of your genetic architecture — all 133+ markers across all 12 domains — before a single recommendation is written. The goal is not to flag individual variants. It is to understand how your unique biological system is wired.

Raw data from 23andMe or AncestryDNA
Your raw DNA file contains hundreds of thousands of SNPs. Meden extracts the 133+ markers with the strongest evidence base for health and longevity.
Variants read in biological context
Methylation variants affect neurotransmitter variants. Hormone variants affect inflammation variants. Every domain informs every other.
Protocol written personally
Supplement forms, doses, timings, and interactions are written for your specific profile — not adapted from a generic template.
Peer-reviewed citations throughout
Every recommendation links to its evidence base. You receive the science, not just the conclusion.
12 Biological Domains

What your genome
tells us about you.

01
Longevity & Anti-Ageing

The genetic architecture of how your cells age — and what slows it. FOXO3 longevity variants, SIRT1 cellular stress response, APOE Alzheimer's and cardiovascular risk, telomere maintenance genes.

FOXO3 · SIRT1 · APOE · TERT · TERC · KLOTHO
02
Energy & Performance

Mitochondrial efficiency, ATP production capacity, endurance vs power architecture, VO2max genetics, and recovery speed between training sessions.

ACTN3 · ACE · PPARA · PPARGC1A · AMPD1 · VEGF
03
Hormone Optimisation

Oestrogen metabolism and clearance, testosterone pathway genetics, cortisol sensitivity and HPA axis regulation, thyroid function, and sex hormone binding globulin.

CYP19A1 · SHBG · NR3C1 · ESR1 · CYP1B1 · AR
04
Skin & Aesthetics

Collagen production and degradation genetics, UV damage response, antioxidant capacity, inflammatory skin response, and the genetic factors behind skin ageing rate.

COL1A1 · MMP1 · SOD2 · MC1R · GSTP1 · AGER
05
Brain & Cognition

Dopamine clearance rate, neuroplasticity and BDNF expression, mood architecture, memory pathway genetics, stress resilience, and neurodegenerative risk markers.

COMT · BDNF · MAOA · APOE · DRD4 · SLC6A4
06
Sleep & Stress

Circadian rhythm genetics, cortisol sensitivity and awakening response, sleep architecture predispositions, and the genetic factors that govern HPA axis resilience.

CLOCK · PER2 · CRY1 · NR3C1 · FKBP5 · ADORA2A
07
Inflammation & Immunity

Baseline inflammatory tone, cytokine production genetics, immune regulation variants, and the markers that predict how aggressively your body responds to cellular stress.

IL-6 · TNF-α · IL-1β · CRP · NF-κB · IL-10
08
Methylation & Detox

MTHFR and the full methylation cycle, sulfur metabolism, glutathione production capacity, phase I and II detoxification pathways, and histamine clearance genetics.

MTHFR · COMT · CBS · GSTP1 · NAT2 · SULT1A1
09
Cardiovascular Risk

Lipid metabolism genetics, homocysteine pathway variants, thrombosis risk, blood pressure regulation, and the genetic architecture behind long-term cardiovascular health.

APOE · MTHFR · F5 · ACE · PCSK9 · LPL
10
Metabolic & Weight

Dietary fat and carbohydrate metabolism, insulin sensitivity genetics, appetite regulation, circadian eating patterns, and obesity risk architecture.

FTO · TCF7L2 · PPARG · ADRB3 · MC4R · ADIPOQ
11
Gut & Sensitivity

Lactose and gluten tolerance genetics, gut permeability predispositions, microbiome diversity markers, and food sensitivity architecture.

LCT · HLA-DQ · DAO · AOC1 · TLR4 · NOD2
12
Drug & Supplement Metabolism

Cytochrome P450 enzyme genetics, caffeine and alcohol metabolism, nutrient absorption variants, and the pharmacogenomic markers that determine how your body processes what you take.

CYP1A2 · CYP2C19 · CYP2D6 · ALDH2 · VDR · GC

Software reads data.
A specialist reads biology.

Every consumer genetics platform runs your SNPs through an algorithm. The algorithm produces the same report structure for every client — with your data filled in. Meden works differently. A genetics and bioengineering specialist reads your full genomic picture before writing a single word. The interactions between your variants — the ones no algorithm captures — are where your most important insights live.

No algorithm. No template.
Your report is written from scratch against your specific variant profile and your stated goals.
Variant interactions are the insight.
A MTHFR C677T result means something different depending on your CBS, your COMT, and your B12 status. Meden reads them together.
Research doses and forms, not generic advice.
Methylcobalamin not cyanocobalamin. Magnesium glycinate not magnesium oxide. The form, the dose, the timing — specific to your biology.
Drug and supplement interaction analysis.
Your current stack is reviewed against your pharmacogenomic profile before any new recommendations are added.
Bloodwork Interpretation

What your blood
tells your genetics.

Available in The Living Blueprint and The Meden Protocol, bloodwork interpretation connects your current biomarkers to your genetic findings — revealing what is actually happening in your body today, in the context of how it is genetically wired.

ApoB & Lp(a)
True cardiovascular risk markers — connected to your APOE and lipid metabolism genetics.
hs-CRP & IL-6
Systemic inflammation — read against your TNF-α and IL-6 genetic baseline.
Homocysteine
Methylation status in real time — the bloodwork expression of your MTHFR genetics.
Fasting insulin & HbA1c
Metabolic health — connected to your FTO, TCF7L2, and insulin sensitivity variants.
Hormone panel
Oestrogen, testosterone, SHBG, cortisol — read against your hormonal architecture genetics.
Thyroid (TSH, fT3, fT4)
Thyroid function — connected to your metabolic and energy production genetics.
Vitamin D, B12, ferritin
Key nutrient status — interpreted against your absorption and metabolism variants.
Biological Age Snapshot
A synthesis of your biomarker picture against functional optimal ranges — not standard lab minimums.

"Your labs are normal. But normal is not optimal. And optimal is different for every genome."

Standard lab reference ranges are built on population averages. Meden interprets your bloodwork against functional optimal ranges — the levels at which research shows the body performs best — and connects every result to your genetic context.


See The Living Blueprint →
Begin

The science is ready.
So is your genome.

Every Meden programme begins with your raw DNA file from 23andMe or AncestryDNA. If you already have data, you can begin today.

View all programmes How it works